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NIH National Institute of Dental and Craniofacial Research (NIDCR) Home page
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Grants & Funding
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Oral & Salivary Cancer Biology Program

The Oral and Salivary Cancer Biology Program supports basic and translational research to improve detection and treatment of cancers of the Oral Cavity, Pharynx, and Salivary Glands. Basic research focuses on susceptibilities and mechanisms that influence tumor initiation, promotion, and progression. Translational research focuses on development of innovative biomarkers, novel diagnostic technologies, and appropriate human specimens to better characterize cancers and improve medical decision making and treatment response evaluation.
More About This Program

Staff Contacts

All Staff Contacts
Dr. Zong Chen
Zhong Chen, M.D., Ph.D.
Director
Oral & Salivary Cancer Biology Program
(301) 529-7083
zhong.chen@nih.gov

Resources

NIDCR Head and Neck Cancer Think Tank Summary

Grantee News

All Grantee News
04 Feb 2025
How Healthy Stem Cells Turn Into Oral Cancer
12 Aug 2024
First Genome-wide Comparison of Vapers and Smokers Finds Similar DNA Changes Linked to Disease Risk

Funding Opportunities & Notices

View All
Title Staff Contact Opportunity number Activity Code Expiration Date
Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
Lillian Shum, Ph.D.
(301) 594-0618
PAR-23-138 S10 06/03/2025
Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed)
Orlando Lopez, Ph.D.
(301) 402-4243
NOT-DE-21-012 R43/R44, R41/R42 09/05/2025
Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards
Lillian Shum, Ph.D.
(301) 594-0618
NOT-OD-23-032 333 10/01/2025
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Lorena Baccaglini, D.D.S., M.S., Ph.D.
(301) 435-7908
PAR-25-239 U01 05/08/2026
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Lorena Baccaglini, D.D.S., M.S., Ph.D.
(301) 435-7908
PAR-23-162 U01 05/08/2026
Notice of Special Interest (NOSI): NIDCR Support for Research on the Physiological Involvement of Oral Cavity in Coronavirus Disease 2019 (COVID-19)
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Amanda Melillo, Ph.D.
(301) 529-7217
NOT-DE-23-004 05/08/2026
Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research
Noffisat Oki, Ph.D.
NOT-OD-24-078 332 06/19/2026
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
Noffisat Oki, Ph.D.
PAR-23-255 R21 09/08/2026
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
Noffisat Oki, Ph.D.
PAR-25-095 R01 09/08/2026
Notice of Special Interest (NOSI): Lymphatic System in Health and Disease (R01)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-HL-23-099 09/08/2026
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
Noffisat Oki, Ph.D.
PAR-25-096 R03 09/08/2026
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
Noffisat Oki, Ph.D.
PAR-23-254 R01 09/08/2026
Notice of Special Interest (NOSI): Research Supplements to Promote Re-Entry, Re-integration into, and Re-training in Health-Related Research Careers (Admin Supp - Clinical Trial Not Allowed)
NIDCR Training
NOT-OD-23-170 333 10/09/2026
Notice of Special Interest: R13 Support for Conferences and Scientific Meetings to Support Consensus Building for Autoimmune Disease Research Related Common Data Elements NOT-OD-24-145 R13 12/14/2026
Notice of NIDCR's Participation in PAR-19-193 "Microbial-based Cancer Therapy-Bugs as Drugs (R01- Clinical Trial Not Allowed)"
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-DE-19-006 01/01/2027
NIDCR Notice of Participation in PA-25-080 "NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)" NOT-DE-25-041 01/01/2027
Notice of NIDCR's Participation in PAR-19-194 "Microbial-based Cancer Therapy-Bugs as Drugs (R21- Clinical Trial Not Allowed)"
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-DE-19-007 01/01/2027
Notice of NIDCR Participation in RFA-CA-21-035 The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-DE-21-005 01/01/2027
Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)
Hiroko Iida, D.D.S., M.P.H.
(301) 594-7404
Zhong Chen, M.D., Ph.D.
(301) 529-7083
PAR-23-170 R01 01/08/2027
Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)
Lillian Shum, Ph.D.
(301) 594-0618
PAR-24-144 R16 01/08/2027
Support for Research Excellence – First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)
Lillian Shum, Ph.D.
(301) 594-0618
PAR-24-145 R16 01/08/2027
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) PAR-24-152 R15 05/08/2027
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
NIDCR Training
PA-24-254 07/13/2027
Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
NIDCR Training
PA-24-253 332, 333, 666 07/18/2027
Notice of Special Interest (NOSI): Advancing Precision Imaging for Enhanced Diagnosis and Treatment of Oral Lesions
Orlando Lopez, Ph.D.
(301) 402-4243
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-DE-25-034 UG3/UH3, R43/R44, R01 09/08/2027
Notice of Special Interest: Womens Health Research
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Preethi Chander, Ph.D.
(301) 827-4620
NOT-OD-24-079 R15, R01, K01 11/05/2027
Notice of Special Interest (NOSI): Understanding the Basic Mechanisms of Immune-related Adverse Events (irAEs) in Cancer Immunotherapy
Preethi Chander, Ph.D.
(301) 827-4620
Zhong Chen, M.D., Ph.D.
(301) 529-7083
Shoba Thirumangalathu, Ph.D.
(301) 594-0652
NOT-CA-24-055 K22, K99/R00, R01 11/06/2027
Notice of Change in Funding Opportunity Expiration Date and Eligible Organizations for "Assessment of Climate at Institutions (ACt) Award (RC2 - Clinical Trial Not Allowed)" (PAR-24-038) NOT-DE-24-007 RC2 01/01/2028
Notice of NIDCR's participation in PAR-18-714, Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15-Clinical Trial Not Allowed) NOT-DE-18-015 01/01/2028
Notice of Changes to NIDCR's Clinical Terms of Award (CToA) Policy
Anna Nicholson, M.S.H.S.
(301) 594-1852
NOT-DE-19-008 01/01/2028
Notice to Extend Expiration Date for PAR-21-084 "NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)"
Preethi Chander, Ph.D.
(301) 827-4620
NOT-DE-24-019 01/01/2028
Notice of Change: Clarification of Budget for PA-20-227 "Administrative Supplements for Research on Dietary Supplements (Admin Supp Clinical Trial Not Allowed)"
Margaret M. Grisius, D.D.S.
(301) 451-5096
NOT-OD-20-148 01/01/2028
Notice of Correction for RFA-DE-25-004 Collaborative Science to Achieve Disruptive Innovations in Dental, Oral and Craniofacial (DOC) Research (RM1 Clinical Trial Not Allowed)
Amanda Melillo, Ph.D.
(301) 529-7217
NOT-DE-25-036 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) FOA NOT-DE-21-020 01/01/2028
Notice of NIDCR Participation in RFA-CA-22-040, The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-DE-22-014 01/01/2028
NIDCR Notice of Participation in PAR-24-075 "Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)"
Tamara McNealy, Ph.D.
(202) 430-1474
NOT-DE-24-009 01/01/2028
Notice of Change Regarding Institutional Eligibility for PAR-19-134 and PAR-19-135 "Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools" NOT-DE-20-019 01/01/2028
Notice of Intent to Reissue PAR-18-845 Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed) and PAR-18-846 (R21 - Clinical Trial Not Allowed) as a Notice of Special Interest (NOSI)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
NOT-OD-21-113 01/01/2028
NIDCR Guidance on Applications for Investigator-Initiated Clinical Trials
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
NOT-DE-21-014 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed)
Lorena Baccaglini, D.D.S., M.S., Ph.D.
(301) 435-7908
NOT-DE-22-008 01/01/2028
Notice of pre-Application Technical Assistance Webinar for RFA-DE-24-003 Collaborative Science to Achieve Disruptive Innovations in Dental, Oral and Craniofacial (DOC) Research (RM1 Clinical Trial Not Allowed)
Amanda Melillo, Ph.D.
(301) 529-7217
NOT-DE-23-016 01/01/2028
NIDCR Notice of Participation in PAR-24-076 "Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)"
Tamara McNealy, Ph.D.
(202) 430-1474
NOT-DE-24-010 01/01/2028
Notice of Informational Webinar for PAR-23-144, STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed) NOT-MD-24-011 01/01/2028
Notice of National Institute of Dental and Craniofacial Research (NIDCR) Participation in PA-18-935 Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)
Jason Wan, Ph.D.
(301) 594-9898
NOT-DE-20-020 01/01/2028
Notice to Extend Expiration Date for PAR-19-145 "NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03)
Lorena Baccaglini, D.D.S., M.S., Ph.D.
(301) 435-7908
NOT-DE-21-017 01/01/2028
Notice to Extend Expiration Date for PAR-20-277: Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21 Clinical Trial Not Allowed)
Preethi Chander, Ph.D.
(301) 827-4620
NOT-CA-22-093 01/01/2028
Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
PAR-25-338 R01 01/08/2028
NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Amanda Melillo, Ph.D.
(301) 529-7217
Zubaida Saifudeen, Ph.D.
(301) 827-3334
William (Bill) Elwood, Ph.D.
(301) 402-1146
PA-25-303 R01 01/08/2028
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)
Zhong Chen, M.D., Ph.D.
(301) 529-7083
PAR-25-346 R21 01/08/2028
NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Amanda Melillo, Ph.D.
(301) 529-7217
Zubaida Saifudeen, Ph.D.
(301) 827-3334
William (Bill) Elwood, Ph.D.
(301) 402-1146
PA-25-304 R21 01/08/2028
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) PAR-25-134 R15 01/08/2028
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
Scott Verbridge, Ph.D.
(301) 594-0676
PAR-25-105 R03 01/08/2028
NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.
(301) 594-4876
Amanda Melillo, Ph.D.
(301) 529-7217
Zubaida Saifudeen, Ph.D.
(301) 827-3334
William (Bill) Elwood, Ph.D.
(301) 402-1146
PA-25-301 R01 01/08/2028

Previously Funded Grants

NIH RePORTER - Research Portfolio Online Reporting Tool (RePORT)

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