The National Dental Practice-Based Research Network (PBRN) is a nationally coordinated program committed to advancing knowledge of dental practice and ways to improve it. The National Administrative and Resource Center is located at the University of Alabama at Birmingham, and the National Coordinating Center is located at the Center for Health Research, Kaiser Permanente Northwest in Portland, Oregon. These centers comprise the infrastructure for and support the implementation of multiple clinical observational studies and clinical studies conducted within the National Dental PBRN.