Roxane Tussiwand, Ph.D.

Our research focuses on understanding how transcription factors modulate lineage differentiation and function of immune subsets.

“To be or not to be…”
Development of hematopoietic cells occurs in the primary lymphoid organs and requires a complex transcriptional network that promotes the progression from an uncommitted self-renewing stem cell progenitor to a mature cell. Upon achievement of a mature state, the genomic landscape as well as the transcriptional profile of each subset will define its functional properties.

Dendritic cells (DC)
Dendritic cells are key players of the immune system. In peripheral tissues DCs capture antigens and present it to T cells. During infections or inflammation DCs initiate and orchestrate adaptive immunity by recognizing pathogens, secreting cytokines and shaping the appropriate inflammatory milieu. Our group is studying the different DC subsets: how they develop and how they function under steady state as well as under inflammatory conditions.

Early hematopoietic lineage commitment
The first choice during lineage commitment appears to split myeloid from lymphoid development. However increasing evidence suggests that lympho-myeloid diversification is not as restrictive. An unexpected heterogeneity characterizes mature subsets. We aim to understand how lymphoid and myeloid commitment is transcriptionally defined and whether the lineage of origin translates into specialized functional properties across different subsets.