Publications
- Kumar P, Tomita T, Gerken TA, Ballard CJ, Lee YS, Weiss LM, Samara NL. A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues. Nat Commun. 2024 May 6;15(1):3792. doi: 10.1038/s41467-024-48253-w.
- Collette AM, Hassan SA, Schmidt SI, Lara AJ, Yang W, Samara NL. An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase. Sci Adv. 2024 Mar;10(9):eadj8829. doi: 10.1126/sciadv.adj8829. Epub 2024 Feb 28.
- Kumar P, Tomita T, Gerken TA, Ballard CJ, Lee YS, Weiss LM, Samara NL. A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is structurally and functionally distinct from host homologues. BioRxiv. 2023. doi: 10.1101/2023.10.26.564164.
- Collins JC, Magaziner SJ, English M, Hassan B, Chen X, Balanda N, Anderson M, Lam A, Fernandez-Pol S, Kwong B, Greenberg PL, Terrier B, Likhite ME, Kosmider O, Wang Y, Samara NL, Walters KJ, Beck DB, Werner A. Shared and distinct mechanisms of UBA1 inactivation across different diseases. EMBO J. 2024 Feb 15. doi: 10.1038/s44318-024-00046-z. Epub ahead of print.
- Verzijl CRC, Oldoni F, Loaiza N, Wolters JC, Rimbert A, Tian E, Yang W, Struik D, Smit A, Kloosterhuis NJ, Fernandez AJ, Samara NL, Ten Hagen KG, Dalal K, Chernish A, McCluggage P, Tabak LA, Jonker JW, Kuivenhoven JA. A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis. Mol Metab. 2022 June;60:101472. doi: 10.1016/j.molmet.2022.101472.
- Zhang L, Mann M, Syed Z, Reynolds HM, Tian E, Samara NL, Zeldin DC, Tabak LA, Ten Hagen KG. Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2109905118. doi: 10.1073/pnas.2109905118.
- May C, Ji S, Zulfeqhar S, Revoredo L, Daniel EJP, Gerken TA, Tabak LA, Samara NL, Ten Hagen KG. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. J Biol Chem. 2020 Aug 28;295(35):12525-12536. doi: 10.1074/jbc.RA120.014700.
- Fernandez AJ, Daniel EJP, Mahajan SP, Gray JJ, Gerken TA, Tabak LA, Samara NL. The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how non-conserved residues dictate its function. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20404-20410. doi: 10.1073/pnas.1902211116.
- Ji S*, Samara NL*, Revoredo L, Zhang L, Tran DT, Muirhead K, Tabak LA, Ten Hagen KG. A molecular switch orchestrates enzyme specificity and secretory granule morphology. Nat Commun. 2018 Aug 29;9(1):3508. doi: 10.1038/s41467-018-05978-9.
- Samara NL*, Gao Y*, Wu J, Yang W. Detection of Reaction Intermediates in Mg2+-Dependent DNA Synthesis and RNA Degradation by Time-Resolved X-Ray Crystallography. Methods Enzymol. 2017;592:283-327. doi: 10.1016/bs.mie.2017.03.022.
- Samara NL*, Datta AB*, Berndsen CE, Zhang X, Yao T, Cohen RE, Wolberger C. Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module. Science. 2010 May 21;328(5981):1025-9. doi: 10.1126/science.1190049.
- Samara NL. Visualizing the three-metal-ion-dependent cleavage of a mutagenic nucleotide. Proc Natl Acad Sci USA. 2022 Jun 28;119(26):e2207180119. doi: 10.1073/pnas.2207180119.
- Wu J, Samara NL, Kuraoka I, Yang W. Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase. Mol Cell. 2019 Oct 3;76(1):44-56.e3. doi: 10.1016/j.molcel.2019.06.046.
- Samara NL, Yang W. Cation trafficking propels RNA hydrolysis. Nat Struct Mol Biol. 2018 Aug;25(8):715-721. doi: 10.1038/s41594-018-0099-4.
- Li CL, Golebiowski FM, Onishi Y, Samara NL, Sugasawa K, Yang W. Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair. Mol Cell. 2015 Sep 17;59(6):1025-34. doi: 10.1016/j.molcel.2015.08.012.
- Samara NL, Ringel AE, Wolberger C. A Role for Inter-subunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity. Structure. 2012 Aug 8;20(8):1414-24. doi: 10.1016/j.str.2012.05.015.
- Samara NL, Wolberger C. A New Chapter in the Transcription SAGA. Curr Opin Struct Biol. 2011 Dec;21(6):767-74. doi: 10.1016/j.sbi.2011.09.004.
*Co-author
