Nadine Samara: Structural Biochemistry Unit

Our Goal

Welcome to the Samara lab. Our group uses structural and biochemical methods to understand how O-glycosyltransferases (GTs) catalyze the biosynthesis of O-glycans that regulate host:microbe and microbe:microbe interactions. Overall, we aim to understand how GTs are regulated, how they recognize and bind substrates, and how they align their substrates for catalysis. We further aim to use structural methods to probe the diverse catalytic mechanisms of O-glycosylation at atomic resolution.