Ashok Kulkarni, Ph.D.

Dr. Ashok Kulkarni's research focuses on understanding the cellular mechanisms that promote pain hypersensitivity using both mouse models and human clinical samples. The ability to perform genetic engineering in mice has allowed for the identification of pain genes that modulate pain signaling. As such, his group demonstrated that the activity of the neuronal enzyme CDK5 has a key role in regulating pain perception. A needed advancement beyond the traditional use of rodent models in pain research has recently occurred as human sensory ganglia have become available from organ transplant donors for scientific study. Dr. Kulkarni's lab has thereby been able to complement his rodent pain models with multi-omic analysis of human dorsal root ganglia from donors with chronic pain conditions like rheumatoid arthritis, diabetic painful neuropathy, and fibromyalgia, which are examples of chronic inflammatory pain, neuropathic pain, and nociplastic pain respectively. Such studies are important as 1 in 5 adults in the U.S. experience chronic pain, where women are more frequently affected than men. Principally, a better understanding of human nociception is vitally needed in order to better design targeted pain drugs that lack the side effects of current treatments, such as with opioids. Work with mouse models and with limited but critically important human neuronal samples will be conducted in the lab with the goal of finding new therapeutic targets to control and alleviate pain hypersensitivity.