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NIH National Institute of Dental and Craniofacial Research (NIDCR) Home page
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    • Research Conducted at NIDCR (Intramural)
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Grants & Funding
  • Notices of Funding Opportunities
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    • Funded Grants (NIH RePORTER)
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Clinical Trials Program

The National Institute of Dental and Craniofacial Research (NIDCR) is committed to identifying effective preventive, diagnostic, and treatment approaches for dental, oral, and craniofacial diseases and disorders. To advance these efforts, the institute supports well-designed and well-executed clinical trials (Phase I, II, III, and IV) that test interventions and have the potential to improve dental, oral, and craniofacial health. These trials should provide scientific evidence that can be used for establishing or changing the standard of care, or for consideration of a change in health care policy.
More About This Program

Staff Contacts

All Staff Contacts
Dena Fischer, D.D.S., M.S.D., M.S.
Dena Fischer, D.D.S., M.S.D., M.S.
Director
Clinical & Practice-Based Research Program, Clinical Trials Program
Center for Clinical Research
(301) 594-4876
dena.fischer@nih.gov

NIDCR News

All NIDCR News
25 Nov 2024
Our Jaw Shape May Foretell Risk of Temporomandibular Disorders
09 Jul 2024
Dental Visits Increase with Support from Pediatric Providers

Grantee News

All Grantee News
27 Aug 2024
NIDCR-funded Study Finds Females Have Lower Salivary Flow Than Males

Funding Opportunities & Notices

View All
Title Staff Contact Opportunity number Activity Code Expiration Date
Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
Lillian Shum, Ph.D.  
(301) 594-0618
PAR-23-138 S10 06/03/2025
Notice of Special Interest (NOSI): Promoting Mechanistic Research on Therapeutic and Other Biological Properties of Minor Cannabinoids and Terpenes
Preethi Chander, Ph.D.  
(301) 827-4620
Tamara McNealy, Ph.D.  
(202) 430-1474
Lorena Baccaglini, D.D.S., M.S., Ph.D.  
(301) 435-7908
Melissa Ghim, Ph.D.  
(301) 529-6570
NOT-AT-22-027 R21, R01, UG3/UH3 07/01/2025
Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed)
Orlando Lopez, Ph.D.  
(301) 402-4243
NOT-DE-21-012 R43/R44, R41/R42 09/05/2025
Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards
Lillian Shum, Ph.D.  
(301) 594-0618
NOT-OD-23-032 333 10/01/2025
Notice of Special Interest (NOSI): Research on Addressing Violence to Improve Health Outcomes
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
NOT-OD-22-167 R21, R01, R34 10/05/2025
Notice of Special Interest (NOSI): Preventive Interventions to Address Cardiometabolic Risk Factors in Populations that Experience Health Disparities
Lorena Baccaglini, D.D.S., M.S., Ph.D.  
(301) 435-7908
NOT-OD-22-154 R01, R21, R34 10/06/2025
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Lorena Baccaglini, D.D.S., M.S., Ph.D.  
(301) 435-7908
PAR-25-239 U01 05/08/2026
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Lorena Baccaglini, D.D.S., M.S., Ph.D.  
(301) 435-7908
PAR-23-162 U01 05/08/2026
Notice of Special Interest (NOSI): NIDCR Support for Research on the Physiological Involvement of Oral Cavity in Coronavirus Disease 2019 (COVID-19)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Amanda Melillo, Ph.D.  
(301) 529-7217
NOT-DE-23-004 05/08/2026
Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research
Noffisat Oki, Ph.D.  
NOT-OD-24-078 332 06/19/2026
Notice of Special Interest (NOSI): Research Supplements to Promote Re-Entry, Re-integration into, and Re-training in Health-Related Research Careers (Admin Supp - Clinical Trial Not Allowed)
NIDCR Training  
NOT-OD-23-170 333 10/09/2026
Notice of Special Interest: R13 Support for Conferences and Scientific Meetings to Support Consensus Building for Autoimmune Disease Research Related Common Data Elements NOT-OD-24-145 R13 12/14/2026
NIDCR Notice of Participation in PA-25-080 "NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)" NOT-DE-25-041 01/01/2027
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Melissa Ghim, Ph.D.  
(301) 529-6570
RFA-NS-24-019 UG3/UH3 01/08/2027
Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)
Lillian Shum, Ph.D.  
(301) 594-0618
PAR-24-144 R16 01/08/2027
Support for Research Excellence – First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)
Lillian Shum, Ph.D.  
(301) 594-0618
PAR-24-145 R16 01/08/2027
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) PAR-24-152 R15 05/08/2027
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
NIDCR Training  
PA-24-254 07/13/2027
Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
NIDCR Training  
PA-24-253 332, 333, 666 07/18/2027
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)
Melissa Ghim, Ph.D.  
(301) 529-6570
PAR-24-293 UG3/UH3 08/19/2027
Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
PAR-25-296 UG3/UH3 10/20/2027
Notice of Special Interest: Womens Health Research
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Preethi Chander, Ph.D.  
(301) 827-4620
NOT-OD-24-079 R15, R01, K01 11/05/2027
Notice of NIDCR's participation in PAR-18-714, Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15-Clinical Trial Not Allowed) NOT-DE-18-015 01/01/2028
Notice to Extend Expiration Date for PAR-21-084 "NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)"
Preethi Chander, Ph.D.  
(301) 827-4620
NOT-DE-24-019 01/01/2028
Notice of Change Regarding Institutional Eligibility for PAR-19-134 and PAR-19-135 "Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools" NOT-DE-20-019 01/01/2028
Notice of Correction to R&R Budget Form for PAR-21-160, NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Margaret M. Grisius, D.D.S.  
(301) 451-5096
Hiroko Iida, D.D.S., M.P.H.  
(301) 594-7404
NOT-DE-21-002 01/01/2028
Notice of Correction for RFA-DE-25-004 Collaborative Science to Achieve Disruptive Innovations in Dental, Oral and Craniofacial (DOC) Research (RM1 Clinical Trial Not Allowed)
Amanda Melillo, Ph.D.  
(301) 529-7217
NOT-DE-25-036 01/01/2028
NIDCR Guidance on Applications for Investigator-Initiated Clinical Trials
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
NOT-DE-21-014 01/01/2028
Notice of Information: Multi-Institute Interest in Pain Research
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Melissa Ghim, Ph.D.  
(301) 529-6570
NOT-NS-22-057 01/01/2028
Notice of Change in Funding Opportunity Expiration Date and Eligible Organizations for "Assessment of Climate at Institutions (ACt) Award (RC2 - Clinical Trial Not Allowed)" (PAR-24-038) NOT-DE-24-007 RC2 01/01/2028
Notice of Corrected Application Forms for PAR-18-547, NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
NOT-DE-18-016 01/01/2028
Notice of National Institute of Dental and Craniofacial Research (NIDCR) Participation in PA-18-935 Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)
Jason Wan, Ph.D.  
(301) 594-9898
NOT-DE-20-020 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Melissa Ghim, Ph.D.  
(301) 529-6570
NOT-NS-24-014 01/01/2028
RESCINDED - NIDCR Policy on Applications for Investigator-Initiated Clinical Trials
NIDCR Training  
NOT-DE-21-004 01/01/2028
Notice to Extend Expiration Date for PAR-19-145 "NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03)
Lorena Baccaglini, D.D.S., M.S., Ph.D.  
(301) 435-7908
NOT-DE-21-017 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed)
Lorena Baccaglini, D.D.S., M.S., Ph.D.  
(301) 435-7908
NOT-DE-22-008 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Prevention and Management of Chronic Pain in Rural Populations (UG3/UH3, Clinical Trials Required)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
NOT-NR-22-015 01/01/2028
NIDCR Notice of Participation in PAR-24-076 "Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)"
Tamara McNealy, Ph.D.  
(202) 430-1474
NOT-DE-24-010 01/01/2028
Notice of Informational Webinar for PAR-23-144, STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed) NOT-MD-24-011 01/01/2028
Notice of Changes to NIDCR's Clinical Terms of Award (CToA) Policy
Anna Nicholson, M.S.H.S.  
(301) 594-1852
NOT-DE-19-008 01/01/2028
Notice of Change: Clarification of Budget for PA-20-227 "Administrative Supplements for Research on Dietary Supplements (Admin Supp Clinical Trial Not Allowed)"
Margaret M. Grisius, D.D.S.  
(301) 451-5096
NOT-OD-20-148 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Melissa Ghim, Ph.D.  
(301) 529-6570
NOT-NS-24-015 01/01/2028
Notice of Intent to Publish a Funding Opportunity Announcement for Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) FOA NOT-DE-21-020 01/01/2028
Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
William (Bill) Elwood, Ph.D.  
(301) 402-1146
PAR-25-062 UH3 01/07/2028
NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
PAR-25-057 UG3/UH3 01/07/2028
NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Amanda Melillo, Ph.D.  
(301) 529-7217
Zubaida Saifudeen, Ph.D.  
(301) 827-3334
William (Bill) Elwood, Ph.D.  
(301) 402-1146
PA-25-301 R01 01/08/2028
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) PAR-25-134 R15 01/08/2028
NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Amanda Melillo, Ph.D.  
(301) 529-7217
Zubaida Saifudeen, Ph.D.  
(301) 827-3334
William (Bill) Elwood, Ph.D.  
(301) 402-1146
PA-25-303 R01 01/08/2028
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
Scott Verbridge, Ph.D.  
(301) 594-0676
PAR-25-105 R03 01/08/2028
NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)
Dena Fischer, D.D.S., M.S.D., M.S.  
(301) 594-4876
Amanda Melillo, Ph.D.  
(301) 529-7217
Zubaida Saifudeen, Ph.D.  
(301) 827-3334
William (Bill) Elwood, Ph.D.  
(301) 402-1146
PA-25-304 R21 01/08/2028

Previously Funded Grants

NIH RePORTER - Research Portfolio Online Reporting Tool (RePORT)

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